Gelator network dynamics in supramolecular gels
Supramolecular gels constitute adjustable materials of great current interest for drug delivery due to their increased viscosity compared to solution and response to triggers such as pH for gel-formation and dissolution. They are characterized by an arrested crystallisation of the low-molecular-weight gelator molecules forming fibrils physically linked by non-covalent interactions such as hydrogen bonds and van der Waals forces. In this proposal for neutron spin-echo spectroscopy and complementary SANS, we aim to specifically address the slow gelator network dynamics in two types of gels, namely Fmoc-FF peptide gels and bis/Urea gels, made with deuterated solvents and protiated gelator molecules. Even though the scattering signal will be weak, it will be accessible with the ILL instruments IN15 and D22, as it has already been detected by BATS at ILL and previous published SANS. The gelator dynamics will fundamentally differ from polymer network dynamics and provide new insights on the stability of gels relevant for drug delivery. This proposal is part of the InnovaXN PhD thesis project of Riccardo Morbidini in collaboration with the industry partner AstraZeneca.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
MORBIDINI Riccardo; CZAKKEL Orsolya; Katharina Edkins; Robert M. Edkins; HOFFMANN Ingo; MARTEL Anne; PORCAR Lionel and SEYDEL Tilo. (2023). Gelator network dynamics in supramolecular gels. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1042
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This data is not yet public
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