Diffusion of small medically relevant proteins in gels
The increasing use of biologics as therapeutic agents brings pharmaceutical benefits such as selectivity and reduced side effects. However, they can be administered only upon injection in liquid formulations with the drawback of a fast uptake, leading to a high frequency of administration. In this regard, gels are attracting attention as pharmaceutical delivery vehicles, because of their higher viscosity compared to liquid formulations guaranteeing a delayed drug release. Supramolecular gels accomplish this task of a tunable viscosity more easily than the classical polymeric gels. Previously, we have established the solvent diffusion in gels and the comparison to the pure bulk for different gels, as well as the diffusion of small guest molecules therein. We now propose to record for the first time the (sub-)nanosecond self-diffusion of Insulin, the peptide hormone used for the treatment of diabetes, and Lysozyme, an enzyme indicated for antimicrobial therapies, within an FmocFF peptide supramolecular gel. We will probe direct and indirect effects, through hydrodynamics, of confinement. This proposal is part of an InnovaXN PhD thesis involving the industrial partner AstraZeneca.
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The recommended format for citing this dataset in a research publication is in the following format:
MORBIDINI Riccardo; Katharina Edkins and SEYDEL Tilo. (2023). Diffusion of small medically relevant proteins in gels. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1044
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This data is not yet public
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