Soft nanoassemblies in different plasma types: competition between protein corona formation and nanoparticles disassembling
Despite undeniable promising results in in vitro and animal experiments, the behavior of nanodrugs in the human body is yet still poorly understood. Indeed, carrying pharmacodynamics studies in a living body is very complex; moreover, the translation from animal tests to human assessments is far from straightforward. We have developed an in vitro methodology enabling to clarify the interactions between nanoparticles and the components of the biological fluids and we now wish to tackle the effect of different kinds of plasma (i.e. from different animal species and from healthy vs sick animals) to try to pinpoint the microscopical specificities leading to different cellular and tissular responses. Our study will focus on the fate of soft lipidic nano-assemblies (NAs) aimed at treating heart ischemia in plasma of two species of rodents mostly used in preclinical trials (i.e. mouse and rat). Our aim is twofold: a) clarifying the competition between the disassembly of NAs and the formation of a corona around them and b) to assess the specificity of different types of plasma on these two phenomenas.
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The recommended format for citing this dataset in a research publication is in the following format:
Frédéric Gobeaux; MARTEL Anne and TESTARD. (2023). Soft nanoassemblies in different plasma types: competition between protein corona formation and nanoparticles disassembling. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1068
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This data is not yet public
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