Quantifying the effect of the lung antioxidant vitamin E on the reaction of an unsaturated lipid with an air pollutant
The air we breathe has a direct impact on our health via interactions of air pollutants with the epithelial lining fluid (ELF) found in our lungs, which can lead to oxidative stress. An important part of the ELF is the surface layer of lipid surfactants and proteins. The reactivity of this layer towards the common atmospheric oxidant ozone has been studied for a number of lung surfactant proxy systems on aqueous surfaces. For cellular membranes, it is well established that vitamin E significantly slows lipid peroxidation by scavenging reactive intermediates. There is a need to determine the effect of co-existing antioxidants such as vitamin E on the oxidation of unsaturated lipids found in the ELF. We propose a neutron reflectometry experiment on mixed deuterated unsaturated lipid (oleic acid)-Vitamin E monolayers being exposed to ozone. We will be able to derive the kinetic effect of vitamin E on the reaction of oleic acid with ozone to draw health implications and to inform detailed models of the reactivity of the ELF.
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The recommended format for citing this dataset in a research publication is in the following format:
MILSOM Adam; BERKEMEIER Thomas; GUTFREUND Philipp; Jack P. Macklin; MISHRA Ashmi; PFRANG Christian; Maximilian W A Skoda and SU Yizhou. (2023). Quantifying the effect of the lung antioxidant vitamin E on the reaction of an unsaturated lipid with an air pollutant. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1083
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