Using rheo-SANS to monitor the structure of in situ forming peptide-like hydrogel drug delivery implants.
We are developing an in situ forming hydrogel implant made of peptide-like molecules to deliver HIV and contraceptive drugs over a prolonged period (greater than 28days). This will remove the need for patients to comply with complex drug regimens, improving adherence to medicines. The implant forms after injection under the skin in response to a phosphatase enzyme trigger. The objective of this project is to use Rheo-SANS on D22 to study fundamental mechanism of gel formation over time and see how the presence of drug relates to changes in the microscopic structure and rheological/mechanical properties important for in situ forming drug-releasing implants. We also wish to see how the underlying structure of the gel responds to increasing levels of shear stress, until the gel breaks, providing information as to how the hydrogel will exist after implantation under the skin. This data will support our existing rheology, microscopy, SANS, DOSY, QENS, spectroscopy and drug release data. This should allow us to tailor diffusion within the gels to drug release kinetics for sustained delivery by modifying the chemical structure and/or formulation of our hydrogel forming peptide.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
LAVERTY Garry; AN Yuming and PORCAR Lionel. (2023). Using rheo-SANS to monitor the structure of in situ forming peptide-like hydrogel drug delivery implants.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1100
This data is not yet public
This data is not yet public
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