Ion-Ion pairing in solutions of guanidinium salts
Structure factors will be measured for aqueous 6M GdmCl D2O solutions labeled with 15N, natN and mixN atomic concentrations of nitrogen. An identical experiment will be conducted for Gdm2CO3. From these measurements the functions SNN(Q) and gNN(r) will be calculated and the nature of the guanidinium-guanidinium interaction examined as a function of counter-ion. Despite the small nature of these differences, with suitable care and appropriate experimental methodologies we have successfully measured comparable differences previously. There is an increasing need for structural data on the nature of this interaction in the field of protein science due to the important role of the guanidinium moiety in the side chain of the amino acid arginine, and the role it plays in protein folding/ protein aggregation. It is also of significance to the mechanism by which guanidinium (one of the most commonly used denaturant) destabilizes proteins.
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JUNGWIRTH Pavel; Henry E. Fischer; HLADILKOVA Jana; MASON Philip and TAVAGNACCO Letizia. (2012). Ion-Ion pairing in solutions of guanidinium salts. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-419
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