Adsorption of proteins by porous carbons
The experiment is to determine the degree of penetration of two model proteins into mesoporous porous carbons, with a view to possible use in haemoperfusion or other clinical applications. Until now this therapy has been limited to small toxin molecules, which are readily adsorbed by microporous carbons. For proteins, carbons with larger pore sizes are needed. The good contrast match between the carbon substrate and D2O ensures high visibility for the SANS signal from the protein. Use of two types of carbon of different pore structure, and the inclusion of one of these carbons with modified surface chemistry (activated carbon), will contribute in discriminating between the steric and chemical effects of this adsorption. It is also important to compare the adsorption of the same molecule (albumin) under two different configurations.
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LASZLO KRISZTINA; GEISSLER Erik; GRILLO Isabelle and SAVINA Irina. (2012). Adsorption of proteins by porous carbons. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-426
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