Variation of lipid layer thickness, internal structure and adhesion of proteins depending on the exposition to water and cell growth medium
Permanent implants such as metallic hip prostheses are widely used and successfully implemented in medicine. The efforts are manifold to develop new implant surface modifications which may prolong the life span of an implant. Titanium and its alloys are the preferred metal materials for bone reconstruction in orthopaedics and dentistry because of their properties such as immunity to corrosion, bio-compatibility, strength, low modulus and density. To improve their performance various coatings are applied. Phospholipid coatings on titanium surfaces have been intensively studied in terms of adhesion, proliferation and differentiation of human bone derived cells, human chondrocytes, human mesenchymal stem cells and of macrophage stimulation. They proved to be a positive factor for cell-implant interactions. The study of the structure of the phospholipid multilayer under liquid conditions in presence of growth medium and Human Serum Albumin (HSA), which is the favorable condition for cell adhesion, will deliver key parameters to understand the interaction between cells and lipid coated implants.
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GOLUB Maksym; HARAMUS Vasyl; LOTT Dieter; MOULIN Jean Francois; SCHREYER Andreas; WATKINS Erik and WILLUMEIT Regine. (2012). Variation of lipid layer thickness, internal structure and adhesion of proteins depending on the exposition to water and cell growth medium. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-447
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