Structure of floating DPPC bilayer in presence of long-chain alcohols
Primary aliphatic alcohols (CnOH, n is the number of alkyl carbons) are general anesthetics, they also display a wide range of toxic effects. In pharmacy, they are used as penetration enhancers in transdermal drug delivery. Their potency in most biological activities depends quasi-parabolically on alkyl length with a maximum at n~10-12. CnOHs partition in the lipid bilayer of biomembranes, changing its physical properties anisotropically depending on the concentration and chain length n. This leads to conformational changes in membrane proteins coupled to structural and dynamical changes of bilayer resulting in biological effects. The neutron reflectometry experiments proposed will determine how CnOH alcohols affect the bilayer structure. As a model membrane system, bilayers prepared from dipalmitoylphosphatidylcholine (DPPC) and freely floating above another bilayer adsorbed on a smooth solid substrate will be used. Final aims of reflectometry experiments will be determination of CnOH effects on the floating bilayer thickness and roughness, on the DPPC and CnOH interface area and on the hydration of bilayer polar regions.
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BALGAVY Pavol; BELICKA Michal; FRAGNETO Giovanna; KUCERKA Norbert and WESTH Peter. (2012). Structure of floating DPPC bilayer in presence of long-chain alcohols. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-449
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