Effect of dendrimer chemistry on the interaction mechanisms with fluid supported lipid membranes
Novel anti-microbial peptide dendrimers (AMPDs) are believed to act on membranes in a non-specific manner by electrostatic and hydrophobic interactions, which decreases the risk of resistance inducement via mutations and transfer of resistance genes between bacteria. In this study, we will investigate the interaction mechanism of four chemically different dendrimers on fluid phase SLBs. The chosen dendrimers differ in level of branching by changes in stereochemistry and by a chlorine unit. They thus have specific properties in terms of shape, functional group accessibility and polarity - properties that may have an impact on the activity towards SLBs. NR is the only technique that provides detailed structural information in the direction perpendicular to the interface, thus enabling us to unambiguously conclude where the dendrimers are located in the lipid bilayer, if they translocate through it, and whether or not the bilayer is solubilized via a detergent-like mechanism. These studies will allow for a systematic investigation of AMPD dendrimers and identification of the dendrimer properties that affect activity and selectivity towards bacteria and the toxicity towards host cells.
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WACKLIN KNECHT Hanna; BARKER Robert; CARDENAS and Tania Kjellerup Lind. (2012). Effect of dendrimer chemistry on the interaction mechanisms with fluid supported lipid membranes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-450
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