Oxidation kinetics in mixed lipid monolayers
Ozone is a toxic pollutant gas present in ambient air. Ozone reacts and destroys unsaturated lipids in lung surfactant present at the air-water interface of the lung and an increase in ozone concentration is correlated with increased risk of death from respiratory failure. In this work we will use selective deuteration to determine the kinetics of the initial process when the unsaturated lipid, 1-palmitoyl-2-oleoyl-sn-glycero-phosphcholine reacts with ozone in the presence of the major saturated lung lipid dipalmitoyl-sn-glycero-phosphocholine. The reaction will be studied on an aqueous subphase at 37 °C using a range of POPC:DPPC ratios and initial surface pressures. We have performed successful preliminary experiments on pure POPC monolayers with selective deuteration of the oleoyl strand but surface pressure measurements indicate that different kinetics are followed in mixed lipid films.
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THOMPSON Katherine; Richard A. Campbell; HEMMING Joanna and RENNIE Adrian R.. (2013). Oxidation kinetics in mixed lipid monolayers. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-483
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