Nucleolipid Anionic Membranes: structural characterizationand interaction with Nucleic Acids
PLN (phosphatidylnucleosides) are phospholipid-based anionic nucleolipids, where a nucleoside is enzymatically attached to the polar head of a lecithin substituting a choline headgroup. In the past years several studies have highlighted that the microstructure of their self-assemblies depends markedly on the kind of nucleic base due to inter polar-head attractive interactions and, moreover, that PLN self assemblies provide negatively charged interfaces decorated with nucleic motifs that can complex complementary nucleic acid strands using, as the driving force, molecular recognition instead of electrostatic interactions. Neutron reflectometry technique can allow a specific investigation on the interaction between nucleolipids' membranes and different (i.e. characterized by different length and nucleobase sequence) single strand nucleic acids, allowing hence to better comprehend the molecular recognition interaction between PLN bioinspired amphiphiles and nucleic acids.
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MONTIS Costanza; BAGLIONI Piero; BERTI Debora; FRAGNETO Giovanna and NYLANDER Tommy. (2013). Nucleolipid Anionic Membranes: structural characterizationand interaction with Nucleic Acids. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-489
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