Influence of substrate roughness and preparation method on supported bilayer structure
Biological contacts such as the articulating cartilage surfaces in human hips or knees often operate under severe conditions (i.e. high load and low speed), which is related to a boundary lubrication regime characterized by a very low friction coefficient. Breakdown of this lubrication can lead to wear of the cartilage and to osteoarthritis. Insights into the molecular origins of cartilage lubrication could lead to more efficient medical treatments, tissue repair and to longer-lasting prostheses. Theoretical models predict that the membrane roughness should increase with increasing substrate roughness. Other theoretical predictions suggest that an complex series of partial unbinding transitions should be observed upon an increase the substrate roughness. As a consequence, the lipid membrane should be smoother than the substrate for large substrate roughnesss. The purpose of this proposal is to measure lipid bilayer coverage, bilayer roughness and substrate-bilayer water thickness as a function of substrate roughness, bilayer method of preparation, buffer content and eventually temperature.
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RIEU Jean Paul; CHAPUIS Pierre; charitat; FRAGNETO Giovanna; MUNTEANU Bogdan; MURALI MOHAN Meera; PETIT Alexandre; SFARGHIU TRUNFIO Ana Maria and WATKINS Erik. (2013). Influence of substrate roughness and preparation method on supported bilayer structure. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-492
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