Porphyrin adsorption and penetration in a polymer-cushioned bilayer
Photodynamic therapy is based on the interaction, in the presence of oxygen, of light with a photosensitive drug that is inactive and nontoxic in the absence of light. Drug molecules bind more or less specifically to the cell membrane and penetrate into the cytoplasm. Subsequent illumination with a laser of an appropriate wavelength induces a photochemical reaction, which produces phototoxic substances such as singlet oxygen or free radicals, leading to tissue necrosis. Photodynamic therapy has many applications, and is considered a promising treatment against retinoblastoma, a malignant childhood intraocular tumour. Porphyrin derivatives are a class of drug molecules that can be used in this therapy. However, these molecules must be chemically modified to tailor specific interaction with cell membranes. In this context the study of the interactions between a model lipid bilayer and novel synthetic porphyrin derivatives is crucial. Understanding the type of interaction and the modifications induced by porphyrin derivatives on the lipid bilayers will help to develop better drug molecules and to understand the recognition mechanism.
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GERELLI YURI; FRAGNETO Giovanna; MICHEL Jean Philippe; PORCAR Lionel and ROSILIO Veronique. (2014). Porphyrin adsorption and penetration in a polymer-cushioned bilayer. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-544
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