Diffusion of active pharmaceutical ingredients in supra-molecular gels
Gels, i.e. solid-liquid colloids, consist of up to 99.9% liquid whilst exhibiting macroscopic characteristics of a solid. This makes them especially interesting in the context of pharmaceutical drug delivery. In order to characterise drug retention and release in these colloidal systems, we have investigated solvent diffusion in supramolecular gels by quasi-elastic neutron scattering on IN6 and LET and found that the solvent diffuses slightly more quickly in the gels than in the bulk solvent. Whilst this behaviour can be of great advantage, i.e. for modified release, it can also hinder the direct release of the drug, and thus has significant bearing on the practical application of drug delivery gels as well as being a fundamentally poorly understood phenomenon in these topical composite materials. Thus, we now propose to investigate the diffusion of drug molecules in pure solvent compared to that in supramolecular gels. We will investigate this in dependence of the temperature, gellator and drug concentration in two different solvents and thus ask for 4 days of beam time on IN16B.
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Katharina Edkins; Robert M. Edkins; SEYDEL Tilo and STEED Jonathan. (2015). Diffusion of active pharmaceutical ingredients in supra-molecular gels. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-574
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