The spatial variation of the persistence length along Widom-601 DNA
The persistence length of DNA is a quantity used to define the flexibility of the molecule. It is a key parameter to describing the conformation of DNA and, as a result, many biological functions of the molecule including how it packs and its interaction with proteins and membranes. The persistence length is probably not constant along the length of the molecule, however. One biological function that may be strongly influenced is histone positioning, which may be driven by local variations in the persistence length. The commonly investigated Widom-601 DNA molecule is known to have a strong histone positioning effect. Spatial variations in the persistence length will result in changes in the conformational structure of DNA, and these will be observable in scattering experiments. We propose to use SANS to measure the conformational structure of Widom-601 in solution as a function of temperature to determine the spatial variation in the persistence length along its helical axis.
Please note that you will need to login with your ILL credentials to download the data.
Download DataThe recommended format for citing this dataset in a research publication is in the following format:
Adrian Gonzalez; ANGUELOV Dimitar; S. Cuesta-Lopez; JOHNSON Mark Robert; MARTY RODA Marta; PEYRARD Michel; PORCAR Lionel; THEODORAKOPOULOS Nikos; TONCHEV Ognyan; VALLE ORERO Jessica; VAN EIJCK Lambert and WILDES Andrew. (2015). The spatial variation of the persistence length along Widom-601 DNA. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-592
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.