Therapeutic nanoparticles with receptor targeting by polymer-ligand constructs for individual cancer therapy
Nanoparticles for individual cancer therapy are modified by NP-core penetrating polymer modules for cell receptor targeting. In contrast to surface binding cholesterol based constructs, these are based to short polyester chains (PLA), which integrate into the nanoparticle core. The therapeutical nanoparticles will be Lanthanide loaded polymer (PLGA, patent: Gutenberg-university), and to a minor extent liposomes (fast development system). The radio-therapeutic entites are non-toxic compounds of elements depicting a high cross section for xray/gamma and neutron beams, Gadolinium, Erbium and Boron, which produce free radicals upon external irradiation. The individual targeting (person and case specific) is obtained by fast binding of receptor ligands (protein: Albumin, thiolated Transferrin; and small ligands as hemin, folate) by disulfide bridges. The structure shall be estimated by deuterium contrast SANS, the stability and development in cell culture media by time resolved SANS in combination with dynamic light scattering DLS. The cell targeting with the ligand excipients (0.5 – 5% of the polymer) shall be compared with a detergent stabilization of the nanoparticles.
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NAWROTH Thomas; DECKER Heinz; FREY Holger; GRILLO Isabelle; HELLMANN Nadja; JOHNSON Raphael; KREBS Lidija; LANGGUTH Peter; SCHMIDBERGER Heinz and SCHWEINS Ralf. (2015). Therapeutic nanoparticles with receptor targeting by polymer-ligand constructs for individual cancer therapy. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-593
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