Effects of Gold Nanoparticles on the Elasticity of Model Lipid Membranes: a Neutron Spin Echo Study
Gold nanoparticles (AuNPs) have been extensively investigated in the past years, for the development of smart and multifunctional devices for theranostics, specific targeted drug delivery or biosensing. In parallel, there has been increasing necessity to evaluate their interaction with biological interfaces, such as lipid membranes, still far from being completely understood. We propose to use NSE to study the effect of four types of nanoparticles (cationic gold nanorods and nanospheres, anionic gold nanoparticles as-synthesized and coated by a protein corona) on the membrane fluidity of POPC liposomes, to provide an overview of the possible structural and functional factors that determine their effect on membranes. In particular, the effects on membrane fluidity will be assessed with the Zilman-Granek model and correlated with the results already obtained with Fluorescence Correlation Spectroscopy on the same stystems.
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MACCARINI Marco; BERGESE Paolo; BERTI Debora; FARAGO Bela; MONTIS Costanza; SCHWEINS Ralf and ZENDRINI Andrea. (2015). Effects of Gold Nanoparticles on the Elasticity of Model Lipid Membranes: a Neutron Spin Echo Study. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-597
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