QENS study of the influence of transmembrane proteins on the dynamics of phospholipid vesicles
Biological membranes are involved in a variety of cell functions as i.a. the regulation of signal and molecular transport into and out of cells. The interactions between the different lipids and proteins which are the main components of the membrane influence the regulation of these cell processes and are thereby strongly coupled to the membrane structure, composition and dynamics. Hence, we intend to study the molecular mobility of fully hydrated 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) phospholipid vesicles in absence and presence of different amounts of the transmembrane protein transferrin receptor (TFRC) as well as the protein dynamics itself. In order to obtain a detailed understanding of the molecular dynamics of biological membranes on an atomistic scale, with high spatial as well as temporal resolution the combination of the complementary methods Quasielastic Neutron Scattering (QENS) and Molecular Dynamics (MD) simulations will be used. MD simulations of DMPC bilayers with the embedded protein TFRC are currently in preparation and will be compared to the QENS experiments. Therefore, we apply for 4 days of beamtime at the backscattering spectrometer IN16B.
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LAUTNER Lisa; SCHINDLER Torben; SEYDEL Tilo and UNRUH Tobias. (2015). QENS study of the influence of transmembrane proteins on the dynamics of phospholipid vesicles. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-598
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