Diffusion of active pharmaceutical ingredients in supra-molecular gels
Preliminary time-of-flight experiments reveal an interesting difference in diffusion between the free bulk solvent and the solvent in supramolecular gels. This observation is remarable, because it is seen at a gelator contents of only 0.3wt%. In the previous experiment we investigated the diffusion of ibuprofen sodium as pharmaceutical drug load in gels and see the same trend of faster diffusion in gels compared to bulk solvent. We now propose to measure two more pharmaceutical drugs, paracetamol and erythromycin, in order to systematically investigate this effect. This data will enable us to draw conclusions towards supramolecular gels as drug delivery vehicle as well as fundamental insight into the diffusion in soft confinements.
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Katharina Edkins; Robert M. Edkins and SEYDEL Tilo. (2016). Diffusion of active pharmaceutical ingredients in supra-molecular gels. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-634
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