DOI > 10.5291/ILL-DATA.9-13-636

This proposal is publicly available since 06/05/2023

Title

Influence of charge on thickness fluctuations in lipid membranes

Abstract

Lipid membrane elastic properties play an important role in the membrane deformations necessary for cell function, motivating significant research efforts to understand the physics underlying biomembrane dynamics. The majority of research to date has focused on model membrane systems composed of zwitterionic lipids; however, nearly all biomembranes are negatively charged at physiological conditions. Accordingly, here we propose to expand the use of neutron spin echo to study thickness fluctuation dynamics in negatively-charged model membranes. Neutron spin echo is the only technique capable of probing the appropriate length scales and time scales to study thickness fluctuation dynamics, and the unique access to the long Fourier times and high flux available on the IN15 instrument is crucial for the proposed experiments. The experiments outlined below will provide new and necessary insights into charge effects on lipid membrane dynamics and elastic properties.

Experimental Report

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Data Citation

The recommended format for citing this dataset in a research publication is in the following format:

Elizabeth G Kelley; BUTLER Paul; FARAGO Bela; NAGAO Michihiro and PORCAR Lionel. (2018). Influence of charge on thickness fluctuations in lipid membranes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-636

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Metadata

Experiment Parameters

  • Environment temperature

    288 to 308 K
  • Experiment energy

    NSE: 6.5 and 10 A
  • Experiment moment

    NSE:0.06 to 0.18 1/A

Sample Parameters

  • Formula

    • DMPG lipid in D2O