Peptide-loaded dendrimers as degradable drug delivery materials; a study of the peptide/dendrimer association using neutron reflection
The use of peptide and protein drugs is quickly increasing; however these drugs are often sensitive to degradation. It is therefore essential to develop new drug delivery systems that protect the peptides from degradation whilst also slowing release rates. Within FORMAMP (EU grant no. 604 182) we have developed a library of biodegradable linear- dendritic (LD) structures as drug delivery carriers for antimicrobial peptides (AMPs). These LDs can form well defined bilayer coatings on plasters and biomaterials that degrade over time and release incorporated AMPs. To evaluate the functionality of these new materials we propose to study different peptide loading techniques (pre- and post- loading) as well as bilayer degradation process.
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MALMSTEN Martin; O. C. J. Andrén; Kathryn Browning; Richard A. Campbell; Sara Malekkhaiat Häffner and NORDSTROM Randi. (2016). Peptide-loaded dendrimers as degradable drug delivery materials; a study of the peptide/dendrimer association using neutron reflection. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-645
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