STRUCTURE OF POLYMER-SUPPORTED LIPID BILAYERS DERIVED FROM NATIVE CELL-MEMBRANE VESICLES
Recently a generic method for producing polymer-supported lipid bilayers (pSLBs) directly from cell-derived native membrane vesicles (NMVs) was discovered. These pSLBs contain essentially all the naturally occurring cell-membrane components of the donor cell line or organelle while still retaining transmembrane protein mobility and activity. These surfaces offer a new paradigm in SLB-based biomimetic surfaces and bioanalytical sensor design. While fluorescence microscopy studies have indicated that there is at minimum a 5 nm hydration layer between the pSLB and the underlying substrate, the use of neutron reflectivity is expected to provide better insight into the architecture of these complex hybrid pSLBs.
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Hudson P. Pace; AGNARSSON Björn; Antonius Armanious; GERELLI YURI; HOOK Fredrik H; MICCIULLA Samantha and SCHNECK Emanuel. (2016). STRUCTURE OF POLYMER-SUPPORTED LIPID BILAYERS DERIVED FROM NATIVE CELL-MEMBRANE VESICLES. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-650