Influence of static electric field on fast flip-flop dynamics in model bilayer systems
The phospholipid bilayer is the basic structural motif of most biological membranes. As such, many biological processes occur within or in the proximity of the cell membrane, and therefore, interest in the properties and behavior of lipids in membranes is considerable. For example, it is found that in nature the lipid distribution across the inner and outer leaflet of cell membranes is asymmetric [1] and this asymmetry plays a prominent role in processes like cell fusion, activation of the coagulation processes and the recognition and removal of apoptotic cells by macrophages. Therefore there is great interest in studying the factors determining lipid movement across membranes, process far from being understood and characterized. During previous Neutron Reflectometry (NR) experiments we discovered that the structure of an asymmetric reconstituted lipid bilayer spontaneously relaxes, on a subsecond time-scale, if the lipids are in the fluid phase i.e. in biological relevant conditions. We propose now to modify the time scale of this process by application of an external electric field to a solid supported membrane in order to capture structural signature of the flip-flop process.
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GERELLI YURI; FRAGNETO Giovanna; KIESEL Irena; PEREZ-SALAS Ursula and PORCAR Lionel. (2016). Influence of static electric field on fast flip-flop dynamics in model bilayer systems. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-651
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