Influence of the protein corona on the interaction between engineered nanoparticles and model membrane system
Engineered nanoparticles (NPs) found large application in medicine as theranostic materials for the diagnosis and therapy of many diseases. The understanding of the interactions of NPs with cell membranes is of fundamental importance both to tune the efficiency of NPs entry in the cell and limit their cytotoxicity. Neutron reflectometry (NR) is a powerful technique widely used to examine model membranes morphology and their response to different effectors. We propose the use of this tool to understand the nature of the interaction between NPs and a model of the cell membrane which consists in a lipid bilayer floating over a first monolayer grafted onto a gold substrate by means of thiolated tethering molecules, in vitro and in a relevant biological environment when NPs are in contact with proteins and form a new biological entity called protein corona NPs (PC). This model of the cell membrane was chosen since the floating bilayer has weaker interactions with the substrate and is free to fluctuate.
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JOLY Loïc; Baldelli Bombelli Francesca; DI SILVIO Desire; FRAGNETO Giovanna and MACCARINI Marco. (2016). Influence of the protein corona on the interaction between engineered nanoparticles and model membrane system. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-655
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