SANS study of a pH-sensitive Polymer Interacting with a Model Lipid Membrane
In order to improve the therapeutic effect of a drug, a great deal of research has been dedicated to developing drug delivery systems that are meant to facilitate the transport of a pharmaceutical compound in the human body. To this end, we have been studying a pH-sensitive polymer, PP-50, and how it interacts with model lipid membranes. It has been hypothesized that PP-50 has two modes of action: at pH = 7.4, it circulates in the extracellular medium, protecting its cargo (a drug molecule), but when pH drops to 5.5, a value characteristic for endosomes, PP-50 changes its conformation and becomes a membrane-disruptive agent, which leads to the drug release within a cell. Unfortunately, the detailed understanding of such triggered response, as well as the molecular mechanism of PP50-lipid membrane interactions remains elusive, which hinders further its further development as a drug delivery system. Using SANS, we aim to obtain a comprehensive picture of molecular interactions of PP50 with liposomes, which would enable rational design of novel polymer with enhanced membrane-perturbing capabilities.
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Jian Ren Lu; CIUMAC Daniela; KLUZEK Monika; LI Zongyi and SCHWEINS Ralf. (2016). SANS study of a pH-sensitive Polymer Interacting with a Model Lipid Membrane. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-660
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