Localisation of Hyaluronic Acid in Lipid Membranes
Osteoarthritis (OA) is the most common arthropathy in Western civilisation. It is caused primarily by the degeneration of cartilage which leads to increased friction in the joints. Hyaluronic acid (HA) is the main component of the synovial fluid which serves as a lubricant within the joints. In healthy conditions, the cartilage is decorated with surface active lipid linings. In a first investigation we exposed model linings to HA solution and observed an increase in the repeat distance of the oligolamellar lipid membranes by a factor of four. In the proposed experiment we now want to localise HA within the lipid model membranes and identify the mechanism responsible for the stabilisation of the swollen bilayers.
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SCHWOERER Felicitas; DAHINT Reiner; GUTFREUND Philipp and TRAPP Marcus. (2016). Localisation of Hyaluronic Acid in Lipid Membranes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-661
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