Novel transmembrane recognition and immobilization phenomena in lipid monolayers at the air/water interface regulated by fluorocarbon gases
The recruitment of fluorinated therapeutic agents and biomarkers at interfaces is an important new focus in drug delivery research with implications in the treatment of cancers and neurodegenerative diseases. We have shown recently that the adsorption in phospholipid monolayers of soluble fluorinated compounds can be strongly enhanced by hydrophobic interactions at the air/water interface with fluorocarbon gases. In collaboration with Colleagues who synthesize the biomarkers, we propose to extend our recent work to a study of the interaction kinetics and composition of the interfacial film using the FIGARO reflectometer at the ILL. First, we will quantify the extent of irreversible recruitment of biomarkers in condensed-phase lipid monolayers. Then, through selective deuteration of spacer groups in the biomarker, we will resolve the partitioning of the biomarker and the gas in fluid-phase lipid monolayers. Neither of these aims has been realized by ourselves or others to date, and answers to these questions by exploiting the unique high flux of FIGARO at low q will pave the way for future work on the design of novel microbubble-based vectors for drug delivery applications.
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KRAFFT Marie-Pierre; Richard A. Campbell; COUNIL Claire; GALERNE Melodie; LIU Xianhe and SHI Da. (2016). Novel transmembrane recognition and immobilization phenomena in lipid monolayers at the air/water interface regulated by fluorocarbon gases. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-662
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