Kinetics of two-step nucleation in protein crystallization studied by real-time SANS
In this proposal we aim to study the two-step nucleation mechanism in protein crystallization by real-time SANS. With the larger volume and no radiation damage of SANS, we can extend our previous successful study using SAXS (A. Sauter et al. J. Am. Chem. Soc.2015, 137, 1485) to a broad experimental conditions. This is extremely important for establishing the real-time method and providing systematic experimental results for our understanding of the nonclassical pathways of protein crystallization. The previous experiment (9-13-620) has demonstrated the method and we wish to continue this work to complete a systematic study.
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ZHANG Fajun; BECK Christian; DA VELA Stefano; FEUSTEL Michal; MAIER Ralph; MATSARSKAIA Olga; MIKORSKI Marcus; ROOSEN RUNGE Felix; Frank Schreiber; SCHWEINS Ralf; SEYDEL Tilo and SOHMEN Benedikt. (2016). Kinetics of two-step nucleation in protein crystallization studied by real-time SANS. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-672
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