A SANS Study of the Shear-Induced Orientational Order of the Nematic Phase of Amyloid Fibrils
SANS will be used to investigate the shear-induced alignment of the nematic phase of amyloid fibrils formed by designed octapeptides. The octapeptides will included sequenced and blocky peptides rich in arginine and phenylalanine such as RFRFRFRF and RRRRFFFF. In the former case, SAXS shows orientation under flow for a 1 wt% sample, however this was not controlled (it resulted from flow into a capillary delivery system at a synchrotron beamline) and there has been no prior systematic study of shear-induced orientation in such systems. SANS is well suited to this study because of the high contrast available using D2O as solvent as well as the elimination of beam damage (associated with longer X-ray experiments during kinetic shear-alignment measurements).
Please note that you will need to login with your ILL credentials to download the data.
Download DataThe recommended format for citing this dataset in a research publication is in the following format:
HAMLEY Ian; BURHOLT Samuel; CASTELLETTO Valeria; DASILVA Emerson; HUTCHINSON Jessica and PORCAR Lionel. (2016). A SANS Study of the Shear-Induced Orientational Order of the Nematic Phase of Amyloid Fibrils. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-674
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.