Investigation of the stratum corneum multilamellar lipid membrane structure in dependence of asymmetric CER[NP]-C24 and CER[AP]-C24
The stratum corneum (SC) as the main penetration barrier of the mammalian skin is very important for terŽrestŽriŽal life[1]. The barrier properties are dependent on the SC lipid matrix, which is comŽpoŽsed of ceramides (CER), cholesterol and free fatty acids. UnŽfortŽunately their molŽecŽuŽlar arrangement is still not completely understood. This led to the development of sev-erŽal different theoretical models, trying to explain SC properties, which are still under deŽba-te[2]. The aim of this study is to yield more information that will help to furŽther supŽport one of these moŽdels. Special focus shall be set to the two most recently proŽpoŽsed models, the arŽma-tuŽre reinforcement model[3, 4] and the asymmetry model[5]. For both models the full extended conformation of CER is indispensable[3, 4, 5]. That for the asymŽmeŽtric CER[NP]-C24 and CER[AP]-C24 shall be inŽvesŽtigated for their influence on the lipid maŽtrix arŽchiŽtecŽture, using neutron diffraction and for the first time defined deuterations within these CER molecules.
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Thomas Schmitt; DEME Bruno and NEUBERT Reinhard. (2016). Investigation of the stratum corneum multilamellar lipid membrane structure in dependence of asymmetric CER[NP]-C24 and CER[AP]-C24. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-677
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