Squalenoyl-adenosine nanoparticles in serum albumine solutions
Nanodrugs are very promising to control drug delivery without burst release and fast metabolization. In this field, the squalenoyl strategy appears as very efficient to increase the pharmacological activity of chosen drugs. It consists in coupling an active drug with a squalene derivative to produce a compound able to form a spherical internally structured nanoassembly through nanoprecipitation process. Recently, the particular case of Squalenoyl-Adenosine attracted large interest for its dramatic efficacy in both experimental models of cerebral ischemia in mice and spinal cord injury in rats. The mechanism of action seems to go through a step of disassembling of the nanoparticles (NPs) as shown by DLS and FRET but a quantitative study such as the one proposed here by SANS is mandatory for providing density numbers, size distribution and internal structure evolution. the aim is to go deeper in the understanding of the specific activity of these NPs.
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TESTARD; Frédéric Gobeaux; GRILLO Isabelle; GUENOUN; marret and Jean-Philippe Renault. (2017). Squalenoyl-adenosine nanoparticles in serum albumine solutions. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-696
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