Determining the effects of headgroup charge on the elastic and viscous properties of model lipid membranes
Biological membranes are highly flexible self-assembled structures that experience dynamic motions ranging from individual lipid diffusion to undulations of micron-sized patches of the membrane. At intermediate length scales, lipid membranes undergo collective bending and thickness fluctuations that involve tens to hundreds of lipids. Importantly, these mesoscale dynamics are governed by the same elastic properties that determine the energy required for large scale membrane deformations necessary for cell functions such as growth and division. Here we propose to measure the effects of headgroup charge on the mesoscale thickness fluctuation dynamics and membrane elastic properties in model lipid bilayers using neutron spin echo (NSE). NSE is the only technique capable of accessing the necessary length scales and time scales to probe these dynamics and thereby provide important insights into the functional significance of charged lipid headgroups in tuning the dynamics of biological membranes.
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Elizabeth G Kelley; BUTLER Paul; FARAGO Bela; NAGAO Michihiro and PORCAR Lionel. (2018). Determining the effects of headgroup charge on the elastic and viscous properties of model lipid membranes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-705
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