Interaction of proteins with surface functionalised crystalline carbon nanoparticles
The potential of nanostructured carbon materials in biomedical applications is in its infancy. In biosensor preparations biomolecules, especially proteins, are immobilised on carbon electrodes by physicochemical methods. Adsorption of proteins on nanocarbons (graphene, nanotubes and fullerenes) is a means of chemically functionalizing the substrate for nanosensor devices. The way in which biomolecules adsorb and migrate on solid surfaces depends on the hydrophobic/hydrophilic character of the substrate, but the matter is poorly understood. Crystalline carbon nanoparticles (CCNP) offer unique chemical, thermal, optical, mechanical, electrical and structural properties with well defined surface geometry that make them ideal candidates in biomedical applications, including protein sensors. Reports on the effect of interactions of proteins with CCNPs on the protein structure and/or the cell morphology are, however, conflicting. Here we propose a combined neutron spin-echo and SANS experiment (using contrast variation) to address this question.
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CZAKKEL Orsolya; Leonardo Chiappisi; GEISSLER Erik and LASZLO KRISZTINA. (2018). Interaction of proteins with surface functionalised crystalline carbon nanoparticles. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-711
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