Interactions between poly(amino amides)and biological systems to gain deeply understand on the mechanism of protection against virus attach
In the framework of a collaboration with chemistry department of University of Milano, we propose to study a new class of linear polyaminoamides molecules, of extremely promising and already proved medical interest, comprising their strong protection against virus infection (mainly HPV and herpes) and their very low toxicity in complex with DNA. We will primarily focus on AGMA1 and ARGO7, cationic agmatine- and arginine- containing polymers, respectively. Particularly intriguing is the mechanism of action of AGMA1, which is so far not fully understood. The current understanding is that its interaction with cell surfaces by means of glycosaminoglycans (HSPG) has a major role in its protective action. Nevertheless, it is active also against viruses whose attachment to the membrane is not dependent by HSPG. We intend to investigate the above indicated properties, i.e. protection against viruses and gene material complexation. The main goals will be to give insights to the mechanism of interaction of the polymers with mucus, constituting the first barrier to the target tissues of their medical application; to study the structural properties of AGMA1 and ARGO7/23bpDNA complexes.
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DI COLA Emanuela; BROCCA Paola; CANTU Laura; DEL FAVERO Elena; GRILLO Isabelle and RONDELLI Valeria Maria. (2018). Interactions between poly(amino amides)and biological systems to gain deeply understand on the mechanism of protection against virus attach. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-780
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