Understanding the interfacial behaviour of bile salts to better engineer lipid emulsions
The current project aims at elucidating how bile salts (BS) structure influences their interfacial behaviour and role during fat digestion. We propose here to characterise lipid/triacylglycerol (lipid/TAG) vesicles, mimicking colloidal structures found in the gastrointestinal tract - TAG being the major type of dietary lipids -, and their ability to facilitate or hinder the adsorption of two structurally distinct BS, sodium taurocholate and sodium taurodeoxycholate, which are known to exhibit different interfacial properties. Time-resolved small-angle neutron scattering beam time is requested here to: 1) resolve the structure of the liposome/water interface and its evolution over time, after interaction with BS and enzymes mimicking the action of digestive fluids, and 2) monitor the formation of equilibrium structures in the bulk during lipolysis, such as mixed micelles of BS and the products of lipolysis.
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Dreiss; GERELLI YURI; GRILLO Isabelle; Richard D. Harvey; PABOIS Olivia and WILDE Pete. (2018). Understanding the interfacial behaviour of bile salts to better engineer lipid emulsions. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-784
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