Fabrication of polyelectrolyte decorated liposomes obtained through layer by layer deposition
The layer-by-layer (LbL) self-assembly method has shown a wide range of applications in modern biotechnology, allowing the fabrication of polyelectrolyte microcapsules for encapsulation and release of active compounds by the coating of colloidal templates such as liposomes. These platforms present promising applications in drug delivery. We study the fabrication of polyelectrolyte microcapsules by the LbL coating of charged liposomes with layers of oppositely charged polyelectrolytes. For this purpose, liposomes formed by mixtures with different compositions of the lipid dioleoylphosphatidylcholine (DOPC) and the charged surfactant dioctadecyl-dimethylammonium bromide (DODAB) have been used as template. The multilayers were built by the sequential adsorption of oppositely charged polyelectrolytes: anionic poly(4-styrenesulfonate sodium salt) (PSS) and cationic poly(allylamine hydrochloride. These polyelectrolytes present good properties to obtain physico-chemical insights on the process of fabrication of the capsules.
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Eduardo Guzmán; F RUBIO Jose Emilio; Armando Maestro; Ana Mateos-Maroto; ORTEGA Francisco; PREVOST Sylvain and Rubio, R.G.. (2018). Fabrication of polyelectrolyte decorated liposomes obtained through layer by layer deposition. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-787
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