Diffusion of active pharmaceutical ingredients in supra-molecular gels
This is a continuation proposal to 9-13-634. In this earlier experiment on IN16B we measured the diffusion of three different drug compounds within a supramolecular gel at 265 and 270 K, and found that depending on their charge and size the diffusion coefficient is either larger, smaller or equal to that found in the solution. We now propose to follow this experiment up with measurements in the new BATS mode on IN16B. Due to the larger energy range of this setup, we will be able to to measure the same samples at approximate body temperature of 310 K, which is pharmaceutically more important for drug delivery. This proposed study on drug-loaded samples complements our already published study on the associated unloaded solvents and gels using both QENS and NMR [Chem.Comm., 2018, 54, 6340]. Importantly, neutron backscattering accesses unique time- and length scales that are not accessible by NMR. Due to the supramolecular scaffold in the gel samples, the different observation scales of backscattering and NMR are fundamentally important.
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Katharina Edkins; APPEL Markus; Robert M. Edkins and SEYDEL Tilo. (2019). Diffusion of active pharmaceutical ingredients in supra-molecular gels. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-795
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