Structure Study of the Interactions of the de Novo Designed Antimicrobial Lipopeptides with the model bacterial membranes
Antimicrobial peptides (AMPs) are potential candidates to treat the infections of some antimicrobial resistant pathogens because of their distinct membrane disruptive mechanism to kill bacteria with little possibility to develop resistance. We have newly developed a series of lipopeptides with extremely short sequences to be potentially applied in industry. We have studied the interactions of AMPs with variety model lipid membranes using the awarded FIGARO beam time, and we firstly published the kinetic adsorption during the peptide and lipid interactions. We have published 2 papers in 2017 and 2 manuscripts are carrying on based on recent discoveries. Here we propose to extend the previous work to the industrial applications to study the interactions of surfactant-like lipopeptides with LPS and DPPG in comparison with DTAB surfactant. The FIGARO reflectometer at the ILL with high flux at low Q is efficient in resolving the kinetic adsorption processes in non-reflecting water (NRW). This experiment is proposed to indicate the applications of the surfactant-like biocides to the treatments of antimicrobial resistance.
Please note that you will need to login with your ILL credentials to download the data.
Download DataThe recommended format for citing this dataset in a research publication is in the following format:
Jian Ren Lu; CIUMAC Daniela; FA Ke; GONG Haoning; Xuzhi Hu; Mingrui Liao and Armando Maestro. (2019). Structure Study of the Interactions of the de Novo Designed Antimicrobial Lipopeptides with the model bacterial membranes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-802
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.