Effect of oxidative stress on polyunsaturated lipid bilayers modulated by cholesterol and head group composition
The oxidation of biological membranes plays key roles in pathological conditions such as inflammation, infection, or sepsis, through direct damage of the cell membrane. Oxidative stress mainly affects phospholipids with polyunsaturated acyl chains, and leads to a complex mixture of products that dramatically alter membrane properties such as 2D structure, bilayer stability, or membrane protein interactions. The roles of different cell lipid components such as cholesterol and head group species in membrane oxidation is complex and still not well understood. Interesting from a pharmaceutical point of view, the exposure of cells to photoactivatable nanomaterials such as TiO2 nanoparticles (NP) induce oxidative stress, with potential application, e.g., as antimicrobial agents. Compositional differences between bacterial and mammalian membranes will likely determine their respective responses to oxidative stress. Our goal here is to use mammalian cell membrane models to elucidate structural consequences of TiO2 NP-induced oxidation, the role of key membrane components such as cholesterol, PC, or PS head groups, and any potential selectivity or modulation caused by them.
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MALMSTEN Martin; Kathryn Browning; Liv Sofia Elinor Damgaard; Sara Malekkhaiat Häffner; Elisa Parra-Ortiz and SAERBECK Thomas. (2019). Effect of oxidative stress on polyunsaturated lipid bilayers modulated by cholesterol and head group composition. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-806
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