Can impaired lipid exchange be in part responsible for the atherogenic properties of ApoE4?
Atherosclerosis, and its clinical consequences of heart attacks and strokes, is the largest killer in the west. Levels of high and low-density lipoproteins (HDL and LDL, respectively) in the blood have been shown to be directly related to the development of this disease. These particles remove or deposit lipids from artery walls, however much about this process is unknown. Therefore, determining and understanding the importance of the bilayer composition and lipid phase is fundamental in the treatment of the disease. The aim of this study is to gain insight into effect the bilayer composition has on the exchange rate of lipids with the HDL mimics, and compare the role of the apolipoprotein present to help determine the specific roles of each of the components in turn.
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Sarah Waldie; CARDENAS; FORSYTH Victor Trevor; GERELLI YURI; GUTFREUND Philipp; HAERTLEIN Michael; Armando Maestro; MARIC Selma; MOULIN Martine; Nicoḷ Paracini and SEBASTIANI Federica. (2019). Can impaired lipid exchange be in part responsible for the atherogenic properties of ApoE4?. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-807
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