Phase transition behaviour in single and floating phospholipid bilayers
Solid-supported lipid bilayers (SLBs) are widely used tools in biological and technological studies, for the investigation of interactions and molecular processes involved in cell function, disease and for sensing applications. Coexistence of ordered and disordered domains, structural and dynamic coupling between leaflets and the structural responses to changes in the environmental parameters such as temperature, are of fundamental interest in all of the above mentioned fields. Recently, time- and temperature-resolved neutron reflectometry allowed us to perform the real-time characterization of the structural changes taking place across phase transitions in solid supported-lipid bilayers (SLBs). We identified the presence of an isothermal phase transition, characterized by a symmetrical rearrangement of lipid molecules in both bilayer leaflets, followed by a thermotropic phase transition, characterized by an independent melting of the two leaflets. We plan now to characterize with better accuracy this unexpected isothermal process and the influence of the substrate in a SLB and floating bilayer systems.
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GERELLI YURI. (2019). Phase transition behaviour in single and floating phospholipid bilayers. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-852
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