Study of DNA-cationic polymer brush interactions for gene delivery
Structural studies of poly(dimethylaminoethyl methacrylate) cationic polymer brushes and its stable uptake of high levels of oligonucleotides using NR are proposed for Gene therapy. Gene therapy, for the introduction of genetic materials into cells, either to compensate for abnormal genes or to make a desired protein, has gained traction for the treatment of a wide range of diseases. DNA is negatively charged, which is subject to degradation in the bloodstream by endogenous nucleases. In this respect, the entrapment of DNA in cationic vectors such as poly(dimethylaminoethyl methacrylate) polymer brushes protects the DNA from nuclease degradation prior to its release from the matrix.
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ZARBAKHSH Ali; ALEXIS Cardee; Julien E. Gautrot and GUTFREUND Philipp. (2020). Study of DNA-cationic polymer brush interactions for gene delivery. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-856
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