Investigating structural organization of cell-penetrating peptides and insulin complexes
In this proposal we want to characterize the physico-chemical properties of self-assembling complexes of cell-penetrating peptides (CPPs) and a therapeutically relevant protein. We have assessed the efficacy of L- and D- form CPPs as potential carriers for intestinal insulin delivery, but we still lack fundamental understanding on the structure of the complexes formed between the two components upon mixing and the effect of this structure on the intestinal delivery efficacy. Scientific literature regarding structural organization of CPP-cargo complexes is currently limited to proposed models for covalent and non-covalent binding of CPPs to insulin or drug delivery systems, emphasizing the need for further characterization of such complexes. By obtaining such insight on structural organization, we will be able to interpret results of efficacy studies to a much higher extent, and thus to tailor the design of intestinal drug delivery components for optimal delivery.
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NIELSEN Hanne Morck; Kathryn Browning; CHAABAN Hussein; Ragna Guldsmed Diedrichsen; Sylvia Klodzinska and PREVOST Sylvain. (2020). Investigating structural organization of cell-penetrating peptides and insulin complexes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-858
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