SANS Characterization of microfluidics-reconstituted HDL particles as a function of apolipoprotein and lipid types
Atherosclerosis in the primary killer disease of the West. HDL removes cholesterol from foam cells, what decreases the risk of atherosclerosis, but its structure not yet fully characterised. We aim to employ microfluidics setup to produce spherical mature HDL particles of controlled lipid and apolipoprotein ApoE compositions - and to investigate their ultrastructure with SANS using contrast variation. We aim to investigate how ApoE isoform, ApoE conformation and cholesterol content impacts the overall shape of the mature HDL particle, what can impact HDL binding to ApoE receptors. This is important, as understanding particle ultrastructure relation to receptor binding efficiency allows designing better HDL treatments and better lipid-based nanoparticles for targeted drug delivery.
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CARDENAS; Yubexi Correa; Dainius Jakubauskas; Nicolò Paracini; PREVOST Sylvain and Sarah Waldie. (2020). SANS Characterization of microfluidics-reconstituted HDL particles as a function of apolipoprotein and lipid types. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-868
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