Interactions of Surfactant with Model Lipid Membranes Studied by Neutron Diffraction
The skin is a barrier to protect our body from hazardous external environment. As the outermost layer of skin, Stratum Corneum (SC) of mammalian epidermis consists of keratin-filled dead corneocytes and extracellular multiple crystalline lamellar lipid, it forms the main barrier against diffusion of substances across the skin. The SC lipids assemble into two coexisting crystalline lamellar phase with repeat distance of ~6 and 13 nm, which refers to short periodicity phase (SPP) and long periodicity phase(LPP), respectively. Surfactant is widely used as drug carrier due to its amphiphilic property and self-assembly ability. However, how the surfactant interacts with model lipid membrane, especially with the LPP and SPP layers of model membrane, is still not clear yet.In this proposal, we will study the interaction of these surfactants with model SC lipid composed of an equimolar mixture of CERs, CHOL and FFAs using neutron diffraction.We try to study the interaction between surfactants and different SC model membranes, and understand these interactions from the architecture and fluidity of surfactant.
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Yao Chen; DEME Bruno; LI Peixun; MA Kun; WANG ZI and WEBSTER John. (2020). Interactions of Surfactant with Model Lipid Membranes Studied by Neutron Diffraction. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-875
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