Effect of the saponins aescin and glycyrrhizin on the bending modulus of yeast extracted fully hydrogenated and deuterated phospholipids.
Biological membranes can interact with saponins, a class of biological substances, due to the amphiphilic nature of saponins. The interaction between lipid membranes and saponins has not been fully understood, especially in case of membranes close to natural systems. Therefore, we want to examine in this work the effect of the saponins aescin and glycyrrhizin on the elasticity of membranes of small unilamellar vesicles composed of phospholipids extracted from yeast P. pastoris. This phospholipid extract shows a higher similarity to living organisms than model membranes consisting of only one kind of lipid. We want to examine the elasticity of the non-deuterated and the deuterated phospholipid membranes in the presence of the two saponins. The use of fully deuterated phospholipids leads to a variation of the contrast and therefore allows to examine the dynamics of saponin embedded into the membrane. In this case we want to resolve possible differences of the full membrane and the saponin part in it. The experiment is proposed for the IN15 spin echo spectrometer.
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GRAEBITZ-BRAEUER Friederike; DARGEL Carina; HELLWEG Thomas; HOFFMANN Ingo and WACKLIN KNECHT Hanna. (2020). Effect of the saponins aescin and glycyrrhizin on the bending modulus of yeast extracted fully hydrogenated and deuterated phospholipids.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-877
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