Effect of the saponins aescin and glycyrrhizin on hydrogenated and fully deuterated phospholipid membranes extracted from yeast P. pastoris
Biological membranes can interact with saponins, a class of biological amphiphiles. The interaction between lipid membranes and saponins has not been fully understood, especially in case of membranes which resemble natural systems. Therefore, we want to examine in this work the effect of the saponins aescin and glycyrrhizin on membranes of small unilamellar vesicles composed of phospholipids extracted from yeast P. pastoris. This phospholipid extract shows a higher similarity to living organisms than the usual model membranes consisting of only one kind of lipid. Furthermore, we want to examine the effect of the two saponins on fully deuterated phospholipids, which were also extracted from yeast. The use of fully deuterated phospholipids leads to a variation of the contrast and therefore allows to examine the distribution of saponin embedded into the membrane. The experiment is proposed for the D11 SANS spectrometer. If this spectrometer is not available, we propose your experiment for the D22 or D33 SANS spectrometer.
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GRAEBITZ-BRAEUER Friederike; HELLWEG Thomas; SABADASCH Viktor; SCHWEINS Ralf; WACKLIN KNECHT Hanna and WIEHEMEIER Lars. (2020). Effect of the saponins aescin and glycyrrhizin on hydrogenated and fully deuterated phospholipid membranes extracted from yeast P. pastoris. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-898
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