Mixed liposomes containing bacterial lipoteichoic-acid (LTA)
Whilst the biological effect of LTA contributing to bacterial infections is widely reported in microbiological and immunological studies, very little is understood on a physicochemical level; for instance, the amphiphilic nature of LTA would drive its self-assembly into different aggregates such as micelles and liposomes, which would be directly relevant to how it mediates interactions with biological surfaces, biofilm formation, and consequent septic shocks. As part of an H2020 Marie Curie fellowship project, we propose a first SANS study of the mixed liposome structures comprising dipalmitoyl phosphatidylglycerol (DPPG), dipalmitoyl phosphatidylethanolamine (DPPE), cardiolipin (CL) (C16:0) and lipoteichoic acid (LTA) in different molar proportions at pH (1.2, 7 and 12) at 25 and 37 oC. This is expected provide information on the LTA induced structural changes in the mixed liposomes. We also propose measurements on aqueous LTA aggregates at different concentrations (0.2, 2, 5 mg/ml-1) in water at 25 and 37 oC to understand their behaviour as aggregated structures.
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BRISCOE WUGE H; BHARATIYA Bhaveshkumar; GUO Xueying; Charlotte Kenton; Lauren Matthews; SCHWEINS Ralf; SLASTANOVA Anna; STEVENS Michael and WANG Gang. (2020). Mixed liposomes containing bacterial lipoteichoic-acid (LTA). Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-912
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