Combined membrane action of UV-triggerable TiO2 nanoparticles and antimicrobial peptides against bacteria-mimicking bilayers
One of the main biomedical challenges nowadays is the development of new and optimised strategies to enhance bacterial killing and overcome antibiotic resistance. In this context, both photocatalytic TiO2 nanoparticles (NP), combined with UV irradiation, and antimicrobial peptides (AMP) are potent antimicrobial agents, but the use of each of them independently present some drawbacks: TiO2 NPs display low selectivity between bacteria and human cells, and AMPs present high sensitivity to proteolytic degradation and low bioavailability. Thus, promising combinations can arise from the use of TiO2 NPs as AMP delivery systems, while AMPs can act as a NP targeting moiety to enhance selectivity against bacteria. Based on our previous studies regarding the effects of different AMPs, UV, and TiO2 NPs on bacterial and mammalian cell membrane models, here we aim to characterise the changes induced in model bacterial membranes by AMP-loaded TiO2 NPs, in combination with UV, by neutron reflectometry. This study is expected to provide unique structural and kinetic information on their joint membrane interactions, disruption, and lipid degradation required for efficient bacterial killing.
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MALMSTEN Martin; Kathryn Browning; MICCIULLA Samantha and Elisa Parra-Ortiz. (2021). Combined membrane action of UV-triggerable TiO2 nanoparticles and antimicrobial peptides against bacteria-mimicking bilayers. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-924
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